Semaglutide + BPC-157 Calculator

These two peptides are NOT injected together. Semaglutide is injected once per week on the same day each week (e.g. every Monday morning). BPC-157 is injected every day, typically in the morning. Keep both schedules consistent — semaglutide's GLP-1 mechanism relies on stable weekly dosing, and BPC-157's GI protective effects are best maintained with daily administration.

Wash your hands. Swab the tops of the semaglutide vial and bacteriostatic water vial with alcohol swabs. Let dry for 15 seconds. Draw the calculated volume of bacteriostatic water and inject it slowly down the glass wall of the semaglutide vial. Wait 60–90 seconds, then gently swirl — never shake — until the powder fully dissolves. The solution should be clear or very slightly yellow. Label the vial with today's date. One reconstituted vial provides multiple weekly doses.

Follow the same process for BPC-157: swab the vial top, inject bacteriostatic water slowly down the glass wall, wait 60 seconds, gently swirl. Label with today's date. A 5 mg vial with 2 mL of bacteriostatic water gives 2,500 mcg/mL — a 250 mcg dose is just 0.10 mL (10 IU), making daily dosing from one vial practical for 20 doses.

Every week on the same day: draw your semaglutide dose (see calculator for your exact IU). Inject subcutaneously into the abdomen, upper thigh, or upper arm. Rotate sites — don't use the same spot two weeks in a row. The semaglutide injection itself may cause mild stinging; injecting slowly over 10–15 seconds reduces this.

Each morning, draw your BPC-157 dose from the reconstituted vial. A 250 mcg dose at 2,500 mcg/mL concentration is 0.10 mL (10 IU) — a very small volume. Inject subcutaneously into the abdomen. This injection is quick because the volume is small. Rotate your injection site daily to different areas of the abdomen.

GI side effects from semaglutide are most pronounced in the 1–3 days following each weekly injection and tend to improve as the body adjusts. Helpful strategies: eat smaller meals more frequently; avoid high-fat, spicy, or strong-smelling foods in the 24 hours after injection; stay well hydrated; inject in the evening rather than morning if daytime nausea is a problem. The BPC-157 in this protocol is included specifically to support GI comfort during this period.

Both reconstituted vials must be stored in the refrigerator at 2–8°C. Semaglutide is particularly sensitive to temperature — never leave it at room temperature for more than a few minutes. When traveling, use a small insulated medication cooler. Discard both vials 28 days after reconstitution, regardless of remaining volume.