CJC-1295 + Ipamorelin Calculator
The most studied GH peptide combination — activating two separate pituitary pathways simultaneously for synergistic growth hormone pulses 5–10× larger than either peptide alone.
Syringe Size
Which syringe will you use? (applies to all peptides below)
CJC-1295
GHRH receptor activation (accelerator)
Vial Size
BAC Water
Dose per Injection
Concentration
1.0 mg/mL
Volume
0.100 mL
Draw to
10.0 IU
Doses / vial
20
Ipamorelin
GHSR activation + somatostatin inhibition
Vial Size
BAC Water
Dose per Injection
Concentration
2.5 mg/mL
Volume
0.080 mL
Draw to
8.0 IU
Doses / vial
25
Stack Overview
What You'll Need
Step-by-Step Guide
Follow these steps in order. Each step assumes you have no prior experience. Read each one fully before doing it.
This combination is most effective when injected on an empty stomach — ideally 2+ hours after your last meal and at least 30 minutes before eating again. The most important injection of the day is the one you take 30–60 minutes before sleep, because growth hormone is naturally secreted most during the first few hours of deep sleep. Eating carbohydrates or fats raises insulin, which directly suppresses the GH response. Protein alone has less impact. The bottom line: eat your last meal 2+ hours before your injection.
Wash your hands thoroughly with soap and water for 20 seconds. Dry with a clean paper towel. Lay a fresh paper towel on your workspace. Place both peptide vials and the bacteriostatic water vial, your syringes, and alcohol swabs on the surface.
Using a fresh alcohol swab for each, wipe the rubber tops of the CJC-1295 vial, the Ipamorelin vial, and the bacteriostatic water vial. Wipe in one direction — don't scrub back and forth. Let each top air-dry for 10–15 seconds. The alcohol needs to evaporate fully before you insert a needle.
Draw the calculated amount of bacteriostatic water into a syringe. Insert the needle into the CJC-1295 vial and slowly drip the water down the inside wall of the glass — not directly onto the powder. This should take 10–15 seconds. Remove the needle, set the vial down, and wait 60 seconds. Then pick it up and gently swirl (do not shake) in slow circles until the powder is completely gone. The solution will be clear and colorless.
Repeat the exact same process for the Ipamorelin vial — draw the correct amount of bacteriostatic water, inject it slowly down the glass wall, wait 60 seconds, then gently swirl until fully dissolved. Label both vials with today's date and the peptide name.
Invert the CJC-1295 vial. Insert a fresh insulin syringe needle through the rubber top. Pull the plunger back slowly to draw your calculated dose (check the IU mark from the calculator above). Slightly overshoot, then slowly push back to your exact target mark to push out any bubbles and ensure a precise dose.
The most common approach is to draw both peptides into the same syringe immediately before injecting — this saves a needle stick. After drawing CJC-1295, keep the same syringe, insert it into the Ipamorelin vial, and draw your Ipamorelin dose. The combined volume should still fit within your syringe. Alternatively, use two separate syringes and inject each at a different site — both are valid approaches. Never pre-mix in a syringe and store — only combine immediately before injection.
The most practical sites for subcutaneous injection are the abdomen (pinch an inch of skin below and to the side of your navel, 2+ inches away from the navel itself) or the upper outer thigh. Rotate sites between injections — don't inject the exact same spot every day. Pinch the skin, insert the needle at a 45° angle, and push the plunger slowly and steadily over 10 seconds.
Withdraw the needle smoothly. Apply gentle pressure with a dry cotton ball or gauze — do not rub, as this can increase bruising. Place the used syringe directly into your sharps container. Refrigerate both vials at 2–8°C.
Dosing Schedule
Typical protocol (once daily, pre-sleep):
CJC-1295: 100–200 mcg subcutaneously, 30–60 minutes before sleep
Ipamorelin: 200–300 mcg subcutaneously at the same time (can be in the same syringe)
Frequency: Daily, 5–7 days per week
Enhanced protocol (twice daily):
Morning injection (fasted, 30+ min before breakfast): CJC-1295 100 mcg + Ipamorelin 200 mcg
Pre-sleep injection: CJC-1295 100–200 mcg + Ipamorelin 200–300 mcg
**Cycle length:** 8–12 weeks on, 4 weeks off is a common research cycle structure. Some protocols run continuously for 6 months with a 1-month break.
Why These Peptides Are Combined
CJC-1295 and Ipamorelin activate two completely different receptor systems in the pituitary gland, and combining them exploits a fundamental piece of physiology: the pituitary has two main "go" signals for releasing growth hormone, and hitting both at the same time is far more effective than hitting either one alone.
CJC-1295 (without DAC, also called Mod GRF 1-29) mimics growth hormone-releasing hormone (GHRH). It binds to the GHRH receptor on pituitary somatotroph cells and triggers GH synthesis and release. Think of it as the "accelerator" signal.
Ipamorelin mimics ghrelin and binds to the GHSR-1a receptor (the ghrelin receptor) on the same cells. It amplifies the GH release signal and — critically — also inhibits somatostatin, the "brake" hormone that normally limits GH secretion. By removing the brake while pressing the accelerator, the combination produces GH pulses that are substantially larger than either peptide can achieve independently.
The other key reason this combination is favored in research: ipamorelin is the most selective GHRP available. Unlike older compounds (GHRP-2, GHRP-6, hexarelin), ipamorelin does not significantly increase cortisol or prolactin, making it a cleaner research tool.
