Cognitive Enhancement
Peptides that support brain function, memory, and neuroprotection
16 peptide profiles in this category. Browse the full directory to explore all 167 research peptides.
N-Acetyl Selank
An acetylated form of Selank with enhanced CNS penetration and bioavailability - producing anxiolytic, nootropic, and immune-modulatory effects via GABA and BDNF pathways.
Pinealon
A tripeptide derived from the pineal gland peptide complex that supports neuronal survival, cognitive function, and circadian rhythm regulation.
Humanin
A 21-amino acid mitochondria-derived peptide with cytoprotective, neuroprotective, and metabolic regulatory effects — a key longevity peptide.
Galanin
Galanin is a 29-30 aa neuropeptide activating GALR1/2/3 receptors to modulate pain, memory, mood, appetite, and autonomic function. Implicated in Alzheimer's disease (expands into hippocampus as cholinergic neurons degenerate).
N-Acetyl Semax
The acetylated, extended-stability form of Semax - an ACTH-derived heptapeptide with potent BDNF-upregulating, neuroprotective, and cognitive-enhancing effects.
Crystagen
Crystagen (Glu-Asp-Arg) is a synthetic tripeptide bioregulator from Prof. Khavinson's research group targeting the brain and CNS. In the same short peptide bioregulator family as Epithalon. Research suggests neuroprotective and gene-regulatory effects in aged neural tissue.
Orexin-B (Hypocretin-2)
Orexin-B (hypocretin-2) is a 28-aa hypothalamic neuropeptide that activates OX2R > OX1R to promote wakefulness and regulate sleep/appetite. Loss of orexin neurons causes narcolepsy. Orexin receptor antagonists are approved for insomnia.
Semax
A nootropic peptide derived from ACTH that enhances cognition, focus, and neuroprotection.
Nociceptin (Orphanin FQ)
Nociceptin is a 17-aa endogenous opioid-like peptide (but anti-opioid at the spinal level) acting on NOP/ORL1 receptors. It modulates pain, anxiety, stress responses, reward, and drug tolerance. Relevant to novel analgesic and antidepressant research.
P21
A novel peptide derived from CNTF (ciliary neurotrophic factor) with potent neurogenic, cognitive-enhancing, and neuroplasticity-promoting effects.
NAD+
Nicotinamide adenine dinucleotide — the central coenzyme of cellular energy metabolism and a key regulator of longevity pathways including sirtuins.
Cerluten
Cerluten (Glu-Asp-Pro) is a Khavinson synthetic tripeptide bioregulator for the nervous system. Proposed to support neuronal gene regulation and nervous system aging. Used in Eastern European anti-aging longevity protocols.
DSIP (Delta Sleep-Inducing Peptide)
A neuropeptide that promotes slow-wave sleep and has broad regulatory effects on stress hormones and pain.
PE-22-28
A truncated spadin analogue that selectively blocks TREK-1 potassium channels to produce rapid, ketamine-like antidepressant and anxiolytic effects without glutamate receptor involvement.
Neurotensin
Neurotensin is a 13-aa neuropeptide in CNS and GI tract that modulates dopamine neurotransmission, reduces pain, regulates gut motility, and has antipsychotic-like properties. Endogenous 'antipsychotic' in dopamine circuits.
Selank
A synthetic anxiolytic peptide derived from tuftsin that enhances GABA transmission, reduces anxiety, and supports cognition without sedation.
Research Tools
Use these tools to plan and compare Cognitive Enhancement protocols.