Curated by Dr. James T. Walker, PhD — Research DirectorProfiles sourced from peer-reviewed literature

Skin & Anti-Aging

Peptides that promote skin health, collagen production, and anti-aging effects

24 peptide profiles in this category. Browse the full directory to explore all 167 research peptides.

Skin & Anti-Aging2,455 views

Palmitoyl Tetrapeptide-7

A palmitoylated Gly-Gln-Pro-Arg peptide that suppresses inflammatory cytokines (IL-6, IL-8) and stimulates collagen production, reducing photoageing and chronic skin inflammation.

View profile
Skin & Anti-Aging2,355 views

Melanotan II

A cyclic alpha-MSH analog with potent tanning, sexual function, and appetite-suppressing effects via broad melanocortin receptor activation.

View profile
Skin & Anti-Aging5 views

Tetrapeptide-21

Tetrapeptide-21 (Lys-Asp-Val-Tyr) is a collagen-stimulating tetrapeptide that activates TGF-beta signaling in dermal fibroblasts to upregulate type I and III collagen synthesis. Compatible with Matrixyl and GHK-Cu.

View profile
Skin & Anti-Aging1,126 views

Melanotan I

An alpha-MSH analog that stimulates melanin production for photoprotection, with a favourable side effect profile compared to Melanotan II.

View profile
Skin & Anti-Aging3,219 views

Syn-Ake

A synthetic tripeptide that mimics the activity of Waglerin-1 from Temple Viper venom, blocking nicotinic acetylcholine receptors to produce muscle-relaxing, anti-wrinkle effects.

View profile
Skin & Anti-Aging3 views

Tripeptide-10 Citrulline (Decorinyl)

Tripeptide-10 Citrulline (Decorinyl, Asp-Lys-Cit) mimics the decorin-binding site on collagen fibrils, promoting organized collagen fiber assembly and potentially reducing scar formation. Used in anti-aging and post-procedure formulations.

View profile
Skin & Anti-Aging2,126 views

Tripeptide-29

Glycyl-prolyl-hydroxyproline (Gly-Pro-Hyp) - the most abundant tripeptide repeat unit in collagen, studied for its direct role in collagen fibril stabilisation and as a collagen synthesis signal.

View profile
Skin & Anti-Aging2,154 views

Snap-8

An eight-residue acetylated peptide that competes with SNAP-25 to modulate neuromuscular junction signalling and reduce expression lines - a peptide alternative to botulinum toxin.

View profile
Skin & Anti-Aging1,983 views

Vialox

Pentapeptide-3V - a synthetic cobra venom-derived peptide that blocks postsynaptic nicotinic acetylcholine receptors, reducing facial muscle contraction for non-injection wrinkle reduction.

View profile
Skin & Anti-Aging6 views

Hexapeptide-11

Hexapeptide-11 (Peptamide-6) is a yeast fermentate-derived hexapeptide that stimulates fibroblast production of collagen, fibronectin, and laminin, and upregulates desmosome proteins involved in skin barrier integrity.

View profile
Skin & Anti-Aging9 views

Myristoyl Pentapeptide-17

Myristoyl Pentapeptide-17 is a fatty-acid-modified pentapeptide studied for eyelash and eyebrow growth promotion by stimulating keratinocyte production of keratin proteins. Found in cosmetic lash serums and brow enhancement formulations.

View profile
Skin & Anti-Aging2,987 views

Palmitoyl Pentapeptide-4 (Matrixyl)

A lipopeptide that stimulates collagen and glycosaminoglycan synthesis in fibroblasts, clinically shown to reduce wrinkle depth by up to 68% over 6 months.

View profile
Skin & Anti-Aging5,215 views

Carnosine

A naturally occurring dipeptide of beta-alanine and histidine found at high concentrations in muscle and brain - potent anti-glycation, antioxidant, and anti-senescence properties have made it a focus of longevity research.

View profile
Skin & Anti-Aging280 views

Decapeptide-12

Decapeptide-12 is a synthetic skin-brightening peptide that competitively inhibits tyrosinase and reduces melanin synthesis in melanocytes.

View profile
Skin & Anti-Aging2,161 views

GHK-Cu (Copper Peptide)

A naturally occurring copper complex with powerful skin regeneration, anti-aging, and wound healing properties.

View profile
Skin & Anti-Aging351 views

Pentapeptide-18 (Leuphasyl)

Pentapeptide-18 (Leuphasyl) is a synthetic enkephalin-mimetic pentapeptide that acts on opioid receptors in skin to relax facial muscles and reduce expression lines.

View profile
Skin & Anti-Aging470 views

Pal-GHK (Palmitoyl Tripeptide-1)

Pal-GHK (Palmitoyl Tripeptide-1, also known as Matrixyl basic) is a palmitoylated form of the GHK tripeptide that enhances skin penetration and collagen stimulation.

View profile
Skin & Anti-Aging415 views

Pal-AHK (Palmitoyl Tripeptide-3)

Pal-AHK (Palmitoyl Tripeptide-3) is a lipopeptide combining the AHK copper-binding tripeptide with a palmitoyl fatty acid for enhanced skin and scalp penetration.

View profile
Skin & Anti-Aging2,285 views

Syn-Coll

Palmitoyl Tripeptide-5 - a TGF-beta mimetic lipopeptide that activates collagen I and III synthesis in dermal fibroblasts by mimicking the TSP-1 sequence that triggers TGF-beta activity.

View profile
Skin & Anti-Aging2,343 views

Nonapeptide-1

A melanocortin-1 receptor antagonist peptide that blocks alpha-MSH binding to inhibit melanin production - used in skin brightening, hyperpigmentation, and melanogenesis research.

View profile
Skin & Anti-Aging447 views

AHK-Cu

Copper tripeptide-3 (AHK-Cu) is a glycine-histidine-lysine copper chelate studied for scalp and skin repair.

View profile
Skin & Anti-Aging4,895 views

Argireline

Acetyl Hexapeptide-3/8 - a SNAP-25 mimetic that reduces muscle contraction at neuromuscular junctions, smoothing expression lines without needles.

View profile
Skin & Anti-Aging388 views

Lipopeptide (Cosmetic)

A broad class of fatty acid-conjugated peptides used in topical skincare research for enhanced dermal penetration and matrix-stimulating activity.

View profile
Skin & Anti-Aging524 views

GHK (Tripeptide-1)

GHK (Gly-His-Lys) is a naturally occurring copper-binding tripeptide found in plasma, involved in tissue repair, anti-inflammatory signaling, and collagen regulation.

View profile

Research Tools

Use these tools to plan and compare Skin & Anti-Aging protocols.

AI Peptide Advisor

online · Claude + Gemini
ask your question...