Growth Hormone Secretagogues

CJC-1295

A modified GHRH analog that provides sustained growth hormone release, often combined with Ipamorelin.

C152H252N44O42SHalf-life: 8 days (DAC form); 30 minutes (no DAC / Mod GRF 1-29)Molar mass: 3368.90 g/mol

⚠ Research & Educational Use Only. CJC-1295 is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.

Medically reviewed by Dr. Amanda Reid, MDWritten by the KnowYourPeptide Research TeamLast updated April 2026
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Key Takeaways
  • Sustained, elevated GH levels over extended periods
  • Enhanced muscle growth and protein synthesis
  • Significant fat loss, particularly visceral fat
  • CJC-1295 is not FDA-approved for human use. It is a research chemical for scientific study only.

Research At a Glance

  • Sustained, elevated GH levels over extended periods
  • Enhanced muscle growth and protein synthesis
  • Significant fat loss, particularly visceral fat
  • Improved recovery from exercise and injury
Calculate CJC-1295 dose

What is CJC-1295?

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) with a significantly extended half-life compared to natural GHRH. It works by binding to the GHRH receptor in the anterior pituitary gland, stimulating the synthesis and secretion of growth hormone. The DAC (Drug Affinity Complex) version of CJC-1295 further extends its half-life to approximately 8 days by covalently binding to albumin in the bloodstream, allowing for once or twice-weekly injections. Without DAC (Mod GRF 1-29), it requires more frequent dosing but produces a more natural pulsatile GH release pattern. CJC-1295 is most commonly combined with Ipamorelin for a synergistic effect on GH release.

Key Research Benefits

Documented effects observed in preclinical and clinical studies on CJC-1295. See all Growth Hormone Secretagogues peptides for comparison.

Sustained, elevated GH levels over extended periods
Enhanced muscle growth and protein synthesis
Significant fat loss, particularly visceral fat
Improved recovery from exercise and injury
Enhanced skin elasticity and collagen production
Better sleep quality and deeper sleep cycles
Increased IGF-1 levels
Anti-aging effects on multiple body systems

Common Stacks

CJC-1295 is frequently combined with the following peptides for synergistic effects. Click any peptide to compare profiles before deciding.

The classic GH stack: CJC-1295 raises baseline GH levels while Ipamorelin delivers clean, timed pulses without cortisol or appetite spikes.

Ipamorelin profile

CJC-1295 provides sustained GH elevation while Tesamorelin's full-length GHRH agonism adds proven visceral fat reduction data.

Tesamorelin profile

CJC-1295 drives GH release which stimulates IGF-1 production; stacking with exogenous IGF-1 LR3 amplifies downstream anabolic signalling.

IGF-1 LR3 profile

Side Effects & Risks

Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports.

Water retention and bloating
Tingling or numbness in extremities (carpal tunnel-like)
Flushing and warmth at injection time
Headaches
Hypoglycemia (low blood sugar) in susceptible individuals
Potential for acromegaly features with chronic excessive use
May increase risk of insulin resistance

Dosing Data from the Literature

Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.

Research Dosing Protocol

CJC-1295 DAC: 1–2 mg once or twice weekly. Mod GRF 1-29 (no DAC): 100 mcg per injection, 1–3 times daily. Always combined with Ipamorelin (100–300 mcg) for optimal results. Common stacking protocol: inject both simultaneously, 30 min before bed or morning on empty stomach.

Enter your vial size and target dose to get the exact injection volume.

Administration in Research Settings

Standard reconstitution and administration methodology for laboratory research use.

Reconstitute with bacteriostatic water. For DAC version: once weekly injection is sufficient. For Mod GRF 1-29: inject simultaneously with Ipamorelin for synergistic GH pulse. Allow 2 hours of fasting before injection for maximum GH release (insulin inhibits GH). Rotate injection sites.

Research Video

Explore Further

Quick Reference

Half-Life
8 days (DAC form); 30 minutes (no DAC / Mod GRF 1-29)
Molar Mass
3368.90 g/mol
Formula
C152H252N44O42S
Legal Status
Research chemical — not FDA approved. Legal to purchase for laboratory research in most countries.
Storage
Lyophilized: -20°C for long-term, 2–8°C for up to 6 months. Reconstituted: 2–8°C for up to 28 days.

Research Use Only

This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.