Semax
A nootropic peptide derived from ACTH that enhances cognition, focus, and neuroprotection.
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Compound Profile
Semax
Key Data
Research reference only
Research Focus
Preclinical data
⚠ Research & Educational Use Only. Semax is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.
- Significant enhancement of memory formation and recall
- Improved focus, concentration, and mental clarity
- Neuroprotective effects — protects against stroke and oxidative damage
- Semax is not FDA-approved for human use. It is a research chemical for scientific study only.
Research At a Glance
- Significant enhancement of memory formation and recall
- Improved focus, concentration, and mental clarity
- Neuroprotective effects — protects against stroke and oxidative damage
- Increases BDNF and NGF (key for brain health and neuroplasticity)
In Plain English
Simple summarySemax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone) -- specifically, it's the ACTH 4-7 sequence extended with a Pro-Gly-Pro tripeptide to improve stability and CNS penetration. It was developed in Russia in the 1980s and is approved there as a pharmaceutical for stroke recovery and cognitive enhancement. It's one of a small number of peptides with actual human trial data for cognition -- not just animal studies. The mechanism involves upregulation of BDNF and NGF (nerve growth factor) in the brain, which is why it's classified as a nootropic rather than a conventional stimulant.
- Significant enhancement of memory formation and recall
- Improved focus, concentration, and mental clarity
- Neuroprotective effects — protects against stroke and oxidative damage
The full scientific detail, mechanisms, citations, and dosing data, follows below.
What is Semax?
Tap any underlined term for an instant definition.
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH). Originally developed in Russia by the Institute of Molecular Genetics, it has been used clinically in Russia for decades to treat stroke, cognitive decline, and nervous system disorders. Semax works by modulating brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), promoting neuroplasticity and neuroprotection. It also has potent antioxidant and anti-inflammatory effects in the CNS. Its mechanism of action includes activation of melanocortin receptors, which influences dopamine and serotonin pathways.
By the Numbers
Key Research Benefits
Documented effects observed in preclinical and clinical studies on Semax. See all Cognitive Enhancement peptides for comparison.
Common Stacks
Semax is frequently combined with the following peptides for synergistic effects. Click any peptide to compare profiles before deciding.
The premier Russian nootropic stack - Semax provides cognitive activation and focus while Selank reduces anxiety without sedation.
Semax boosts daytime cognitive function while DSIP improves slow-wave sleep - together they cover the full cognitive enhancement cycle.
Semax is neuroprotective short-term while Epitalon targets long-term telomere health - a popular nootropic longevity stack.
Side Effects & Risks
Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports. View all peptides' side effects →
Dosing Data from the Literature
Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.
Typical research dosing: 200–900 mcg intranasally, 1–3 times daily. Intranasal is the preferred route (avoids first-pass metabolism). Cycles of 2–4 weeks are common, followed by equal breaks to prevent receptor downregulation.
Administration in Research Settings
Standard reconstitution and administration methodology for laboratory research use.
Semax is typically self-administered intranasally using a nasal spray bottle. Tilt head back slightly, spray into each nostril alternating, and breathe gently. For the N-acetyl form (NA-Semax Amidate), doses are typically 25–100 mcg due to higher potency. Best taken in the morning or early afternoon — avoid evening use due to stimulating effects.
Research Video
Medical Expert Videos
Physicians, researchers, and pharmacologists explain Semax, covering mechanisms of action, clinical context, and study findings.
Videos sourced from YouTube search. KnowYourPeptide does not endorse any individual creator. For research education only.
The Bottom Line
Semax has a growing body of preclinical evidence and a well-characterised safety profile in research settings. The most-studied application is: significant enhancement of memory formation and recall.
The most commonly reported side effect in research subjects is mild anxiety or restlessness at high doses. It is a research chemical, not approved for human use.
Frequently Asked Questions
Explore Further
Quick Reference
Research Articles
- Selank: The Nootropic Peptide for Anxiety and Mental Clarity8 min read
- Semax Dosage Guide: Nasal and Injection Administration, Reconstitution, and Dosing Protocol6 min read
- Selank vs Semax: Comparing the Russian Nootropic Peptides7 min read
- Cortagen: Neuronal Research in Cellular Aging and Stress Models6 min read
How It Compares
Selank targets anxiety primarily; semax targets cognition and neuroprotection primarily. They're complementary rather than competitive -- many researchers combine them. For pure nootropic effect in a healthy baseline, semax is typically the primary compound. For anxiety-driven cognitive impairment, selank may address the root cause more directly.
Compare Semax side-by-sideResearch Use Only
This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.