Skin & Anti-Aging

GHK-Cu (Copper Peptide)

A naturally occurring copper complex with powerful skin regeneration, anti-aging, and wound healing properties.

C14H23CuN6O4Half-life: Variable (topical bioavailability varies widely)Molar mass: 403.90 g/mol

⚠ Research & Educational Use Only. GHK-Cu (Copper Peptide) is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.

Medically reviewed by Dr. Amanda Reid, MDWritten by the KnowYourPeptide Research TeamLast updated April 2026
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Key Takeaways
  • Stimulates collagen and elastin synthesis — reduces wrinkles and improves skin elasticity
  • Accelerates wound healing
  • Reduces inflammation and oxidative stress
  • GHK-Cu (Copper Peptide) is not FDA-approved for human use. It is a research chemical for scientific study only.

Research At a Glance

  • Stimulates collagen and elastin synthesis — reduces wrinkles and improves skin elasticity
  • Accelerates wound healing
  • Reduces inflammation and oxidative stress
  • Promotes hair follicle growth and combats hair loss

What is GHK-Cu (Copper Peptide)?

GHK-Cu is a naturally occurring copper complex first isolated from human plasma. It consists of the tripeptide glycyl-L-histidyl-L-lysine bound to a copper(II) ion. It is found naturally in blood, urine, and saliva. GHK-Cu has been extensively studied for its remarkable ability to stimulate collagen and elastin production, promote wound healing, reduce inflammation, and exert antioxidant effects. It acts as a powerful activator of gene expression, upregulating hundreds of genes involved in tissue repair while downregulating genes associated with inflammation and tumor progression. It is widely used in cosmetic formulations but also studied for systemic anti-aging effects.

Key Research Benefits

Documented effects observed in preclinical and clinical studies on GHK-Cu (Copper Peptide). See all Skin & Anti-Aging peptides for comparison.

Stimulates collagen and elastin synthesis — reduces wrinkles and improves skin elasticity
Accelerates wound healing
Reduces inflammation and oxidative stress
Promotes hair follicle growth and combats hair loss
Activates protective genes (over 4000 genes modulated in studies)
Antioxidant effects — removes oxidized lipids and free radicals
Anti-cancer gene expression patterns observed in research
Improves skin density and thickness

Common Stacks

GHK-Cu (Copper Peptide) is frequently combined with the following peptides for synergistic effects. Click any peptide to compare profiles before deciding.

Both target aging at the cellular level - GHK-Cu via extracellular matrix and Epitalon via telomere regulation.

Epitalon profile

GHK-Cu accelerates surface wound healing while TB-500 handles deeper tissue and vascular repair.

TB-500 profile

A comprehensive anti-aging skin and cell stack - GHK-Cu restores extracellular matrix while SS-31 restores mitochondrial function.

SS-31 (Elamipretide) profile

Side Effects & Risks

Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports.

Generally very well-tolerated — among the safest peptides studied
Mild skin irritation with high concentrations (topical)
Possible temporary redness or warmth at injection site
Rare allergic reactions in copper-sensitive individuals
Darkening of skin possible with systemic use at high doses

Dosing Data from the Literature

Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.

Research Dosing Protocol

Topical: 1–3% concentrations in serums/creams applied 1–2x daily. Systemic (research): 1–2 mg subcutaneously daily or every other day. Hair regrowth protocols often use topical solutions at 0.1–1%. Systemic administration provides more comprehensive effects but topical is more practical for most applications.

Enter your vial size and target dose to get the exact injection volume.

Administration in Research Settings

Standard reconstitution and administration methodology for laboratory research use.

For topical use: apply to clean skin, avoid eye contact, let absorb fully before applying other products. For subcutaneous injection: reconstitute lyophilized form with bacteriostatic water; inject in areas near target tissues. For hair loss: mix topical solution and apply directly to scalp daily.

Research Video

Explore Further

Quick Reference

Half-Life
Variable (topical bioavailability varies widely)
Molar Mass
403.90 g/mol
Formula
C14H23CuN6O4
Legal Status
Available in cosmetic products without prescription. Research-grade systemic form is a research chemical — not FDA approved for systemic human use.
Storage
Lyophilized: store at -20°C for long-term, or 2–8°C for up to 6 months. Reconstituted: 2–8°C for up to 30 days. Topical formulations: follow label storage instructions (typically room temperature).

Research Use Only

This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.