Ipamorelin Dosage Guide: Vial Reconstitution, Injection Volumes, and GH Protocol

Ipamorelin is the most selective growth hormone secretagogue (GHS) available for research, producing robust GH pulses with minimal cortisol or prolactin elevation. This guide covers practical reconstitution and dosing for research protocols.

What Vials Typically Come In

Ipamorelin research vials are most commonly available in:

• 2 mg vials
• 5 mg vials
• 10 mg vials (for combination protocols)

How to Reconstitute Ipamorelin

Standard reconstitution for a 2 mg vial:

1. Clean rubber stopper with alcohol swab; allow to dry

2. Draw 1–2 mL bacteriostatic water into a syringe

3. Inject water slowly down the vial wall (do not aim at the powder)

4. Swirl gently — do not shake

5. Allow 2 minutes for complete dissolution

Concentration examples:

• 2 mg + 1 mL BW → 2000 mcg/mL
• 2 mg + 2 mL BW → 1000 mcg/mL
• 5 mg + 2 mL BW → 2500 mcg/mL

The 2000 mcg/mL concentration (2 mg in 1 mL) is popular, providing 10–15 injections per vial at standard 100–200 mcg doses.

Standard Research Dosage Ranges

Most referenced research protocol: 200 mcg subcutaneous, once daily at bedtime, often combined with CJC-1295 or sermorelin.

Injection Volume Table

Using a 2000 mcg/mL reconstituted solution (2 mg in 1 mL BW):

Use the Dose Calculator to calculate volumes for any concentration or target dose.

Frequency, Timing, and Cycle Length

• Timing: Bedtime injection is preferred to amplify natural nocturnal GH pulse; pre-workout timing used in some protocols
• Fasting: Best administered fasted or 90+ minutes after the last meal; carbohydrate-rich meals blunt GH response
• Cycle length: Studies up to 12 months; 3–6 months is the most common research duration
• Cycling: Ipamorelin shows minimal receptor desensitization — continuous protocols are used without the "on/off" cycling needed for some GHS compounds

Combination with GHRH Analogues

Ipamorelin is most commonly co-administered with a GHRH analogue:

• CJC-1295 (Mod GRF 1-29) + Ipamorelin: Inject simultaneously at the same site or separate sites
• The combination produces GH pulses 3–5x greater than either alone

Storage

• Lyophilised vials: -20°C
• After reconstitution: 2–8°C; use within 28 days
• Avoid freeze-thaw cycles