Vesilut
Vesilut is a short peptide bioregulator from Khavinson's research program, originally derived from urinary bladder tissue and studied for bladder cell function and urogenital aging research.
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⚠ Research & Educational Use Only. Vesilut is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.
- Supports bladder epithelial cell function in aging models
- Modulates gene expression in urothelial cells
- Part of the Khavinson short peptide bioregulator system
- Vesilut is not FDA-approved for human use. It is a research chemical for scientific study only.
Research At a Glance
- Supports bladder epithelial cell function in aging models
- Modulates gene expression in urothelial cells
- Part of the Khavinson short peptide bioregulator system
- Studied for age-related urogenital decline
What is Vesilut?
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Vesilut is a short peptide bioregulator derived from urinary bladder tissue peptide fractions, developed as part of Professor Vladimir Khavinson's research program at the St. Petersburg Institute of Bioregulation and Gerontology. Like other peptides in this program (Epithalon from pineal, Cortagen from cortex, Ovagen from liver), Vesilut is proposed to act as a tissue-specific epigenetic regulator for bladder epithelium.
What It Is
- A short oligopeptide derived from bovine urinary bladder tissue fractions
- Part of the Khavinson short peptide bioregulator research series
- Proposed tissue-specific action on urothelial and bladder smooth muscle cells
- Studied in the context of age-related urogenital decline and bladder function
How It Works
- Based on the Khavinson hypothesis: short peptides enter target cell nuclei and interact with gene promoter regions, modulating transcription of tissue-specific genes
- In bladder cell models, Vesilut is proposed to restore gene expression patterns toward those seen in younger tissue
- Proposed to influence smooth muscle cell proliferative activity and reduce apoptosis in aged urothelial cultures
- Similar to other tissue-specific short peptides: primarily studied via changes in cell cycle markers and gene expression profiles
Key Research Findings
- Urothelial cell cultures: Vesilut at 0.01-10 ng/mL restored proliferative activity in aged urothelial cell cultures by 15-25% vs untreated aged controls (measured by BrdU incorporation)
- Gene expression: RT-PCR analysis showed upregulation of BCL-2 (anti-apoptotic) and downregulation of pro-inflammatory cytokines in treated aged bladder epithelial cells
- Aged rodent models: In 24-month-old rats, Vesilut administration (10 mcg/kg, 10-day course) reduced markers of bladder wall fibrosis in histological analysis
Dosing From the Literature
- Animal studies: 1-10 mcg/kg intraperitoneal or subcutaneous injection, daily for 10-day cycles
- Russian clinical protocols: 10-30 mg oral (enteric-coated) or 1-5 mg subcutaneous, 10-day courses repeated 2-4 times per year
Storage and Handling
- Lyophilised: 2-8 degrees C; stable 24 months
- Reconstituted: 2-8 degrees C; use within 14 days
Key Research Benefits
Documented effects observed in preclinical and clinical studies on Vesilut. See all Immune System peptides for comparison.
Side Effects & Risks
Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports. View all peptides' side effects →
Dosing Data from the Literature
Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.
Administration in Research Settings
Standard reconstitution and administration methodology for laboratory research use.
In research protocols, administered subcutaneously or orally in 10-day cycles repeated 2-4 times per year.
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Research Use Only
This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.