Taxorest

Taxorest is a peptide bioregulator from Professor Khavinson's research program, derived from tracheal/tracheobronchial tissue, targeting the upper and central airways. It is differentiated from Chonluten (which targets pulmonary alveolar tissue) by its focus on the tracheal and bronchial epithelium — the ciliated airway epithelium responsible for mucociliary clearance.

Age-related changes in the respiratory epithelium include: reduced cilia beat frequency, impaired mucociliary transport (critical for clearing inhaled particles and pathogens), reduced secretory IgA production, decreased airway stem cell proliferation capacity, and impaired repair after injury. These changes contribute to increased susceptibility to respiratory infections and slower recovery in elderly individuals.

Taxorest is proposed to target respiratory epithelial cell gene expression, potentially supporting ciliated cell maintenance, mucus production regulation, and epithelial barrier function. In the Khavinson bioregulator system, it is often paired with Chonluten for comprehensive respiratory tract support.

As with other Khavinson bioregulators, the primary evidence base consists of publications from the St. Petersburg Institute of Bioregulation and Gerontology in Russian-language journals and translated journals (Advances in Gerontology, Bulletin of Experimental Biology and Medicine). Independent replication in Western clinical settings is limited.