Muscle & Performance

Follistatin-344

A naturally occurring protein that inhibits myostatin and activin, promoting dramatic muscle growth.

Protein — varies by glycosylationHalf-life: 35–38 hoursMolar mass: 37000.00 g/mol

⚠ Research & Educational Use Only. Follistatin-344 is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.

Medically reviewed by Dr. Amanda Reid, MDWritten by the KnowYourPeptide Research TeamLast updated April 2026
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Key Takeaways
  • Inhibits myostatin — removes the ceiling on muscle growth
  • Dramatically increases muscle mass and strength
  • Promotes satellite cell proliferation for muscle repair
  • Follistatin-344 is not FDA-approved for human use. It is a research chemical for scientific study only.

Research At a Glance

  • Inhibits myostatin — removes the ceiling on muscle growth
  • Dramatically increases muscle mass and strength
  • Promotes satellite cell proliferation for muscle repair
  • Reduces body fat through metabolic effects
Calculate Follistatin-344 dose

What is Follistatin-344?

Follistatin-344 is a naturally occurring glycoprotein and one of the most potent muscle-building compounds studied. It works primarily by binding to and inhibiting myostatin (GDF-8) and activin, two proteins that act as negative regulators of muscle growth. By blocking myostatin, follistatin removes the body's natural brake on muscle hypertrophy, enabling significantly greater muscle growth than would otherwise be possible. Research in both animals and humans has shown remarkable results — in some gene therapy studies, subjects experienced 15–20% increases in muscle mass within weeks. It also plays roles in follicle-stimulating hormone regulation and neural development.

Key Research Benefits

Documented effects observed in preclinical and clinical studies on Follistatin-344. See all Muscle & Performance peptides for comparison.

Inhibits myostatin — removes the ceiling on muscle growth
Dramatically increases muscle mass and strength
Promotes satellite cell proliferation for muscle repair
Reduces body fat through metabolic effects
Enhances recovery from exercise
May support bone density
Shown to reverse muscle wasting in animal models of muscular dystrophy

Common Stacks

Follistatin-344 is frequently combined with the following peptides for synergistic effects. Click any peptide to compare profiles before deciding.

Follistatin-344 removes the myostatin brake on muscle growth while IGF-1 LR3 provides the direct anabolic signal for hypertrophy and hyperplasia.

IGF-1 LR3 profile

Follistatin-344 removes the myostatin brake on muscle growth while Ipamorelin provides the GH signal to drive anabolism.

Ipamorelin profile

CJC-1295 sustains elevated GH output, complementing Follistatin-344's removal of growth-limiting factors.

CJC-1295 profile

Side Effects & Risks

Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports.

Limited human research — long-term safety profile not fully established
Potential for abnormal organ growth with long-term use
Injection site reactions
Possible interference with FSH signaling (reproductive effects)
Uncertain cancer risk (promotes cell growth broadly)
Tendon and joint stress from rapid muscle gain

Dosing Data from the Literature

Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.

Research Dosing Protocol

Research dosing: 100 mcg per day for 10 days (common protocol). More aggressive protocols use 300–500 mcg total over 5–7 days. Due to limited human research, caution is strongly advised. Not recommended for extended or repeated use without thorough understanding of risks.

Enter your vial size and target dose to get the exact injection volume.

Administration in Research Settings

Standard reconstitution and administration methodology for laboratory research use.

Reconstitute with bacteriostatic water. Intramuscular injection into target muscle groups may produce localized effects, while subcutaneous injection produces more systemic effects. Use the minimum effective dose. Long breaks between cycles are essential.

Research Video

Explore Further

Quick Reference

Half-Life
35–38 hours
Molar Mass
37000.00 g/mol
Formula
Protein — varies by glycosylation
Legal Status
Research chemical — not FDA approved for human use. Legal for research purposes in most jurisdictions. Banned by WADA in competitive sports.
Storage
Lyophilized: -20°C for long-term storage. Reconstituted: 2–8°C for 5–7 days. This protein is more fragile than smaller peptides — handle with care, avoid excessive agitation.

Research Use Only

This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.