Epitalon (Epithalon)
A tetrapeptide known as the 'fountain of youth peptide' for its telomere-lengthening and anti-aging properties.
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Compound Profile
Epitalon (Epithalon)
Key Data
Research reference only
Research Focus
Preclinical data
⚠ Research & Educational Use Only. Epitalon (Epithalon) is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.
- Activates telomerase — extends telomere length (anti-aging at cellular level)
- Regulates melatonin production and circadian rhythm
- Improves sleep quality, particularly in older subjects
- Epitalon (Epithalon) is not FDA-approved for human use. It is a research chemical for scientific study only.
Research At a Glance
- Activates telomerase — extends telomere length (anti-aging at cellular level)
- Regulates melatonin production and circadian rhythm
- Improves sleep quality, particularly in older subjects
- Potent antioxidant effects
In Plain English
Simple summaryThink of Epitalon (Epithalon) as a signalling molecule your body already recognises, it doesn't introduce anything foreign, it tells specific cells to do things they're already capable of doing, just more efficiently.
- Activates telomerase — extends telomere length
- Regulates melatonin production and circadian rhythm
- Improves sleep quality, particularly in older subjects
The full scientific detail, mechanisms, citations, and dosing data, follows below.
What is Epitalon (Epithalon)?
Tap any underlined term for an instant definition.
Epitalon (also spelled Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian gerontologist Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is considered one of the most important anti-aging peptides in research. Epitalon's primary mechanism is the activation of telomerase, the enzyme responsible for lengthening telomeres — the protective caps on chromosomes that shorten with each cell division. Shorter telomeres are directly associated with cellular aging. By activating telomerase, Epitalon has been shown to extend telomere length, potentially slowing or reversing some aspects of cellular aging. It also regulates melatonin production by the pineal gland.
Key Research Benefits
Documented effects observed in preclinical and clinical studies on Epitalon (Epithalon). See all Immune System peptides for comparison.
Common Stacks
Epitalon (Epithalon) is frequently combined with the following peptides for synergistic effects. Click any peptide to compare profiles before deciding.
A longevity-focused cognitive stack - Epitalon supports cellular aging and Semax provides neuroprotection and BDNF upregulation.
Both address aging at a fundamental level - Epitalon via telomere maintenance and NAD+ via sirtuin activation and DNA repair.
Epitalon's pineal gland effects pair well with DSIP's deep-sleep induction for a circadian rhythm restoration protocol.
Side Effects & Risks
Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports. View all peptides' side effects →
Dosing Data from the Literature
Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.
Typical research dosing: 5–10 mg daily for 10–20 days, repeated 1–2 times per year. This cyclic protocol mirrors what was used in human longevity studies. Intranasal administration (10–20 mg/day) is also used. Some researchers use 100–200 mcg per kg body weight.
Administration in Research Settings
Standard reconstitution and administration methodology for laboratory research use.
Reconstitute with bacteriostatic water. Administer subcutaneously in the morning or evening. Annual cycles of 10–20 days are the most researched protocol. Intranasal delivery is possible but less common. Some combine with other anti-aging peptides like GHK-Cu and Thymalin.
Research Video
Medical Expert Videos
Physicians, researchers, and pharmacologists explain Epitalon (Epithalon), covering mechanisms of action, clinical context, and study findings.
Videos sourced from YouTube search. KnowYourPeptide does not endorse any individual creator. For research education only.
The Bottom Line
Epitalon (Epithalon) has a growing body of preclinical evidence and a well-characterised safety profile in research settings. The most-studied application is: activates telomerase — extends telomere length.
The most commonly reported side effect in research subjects is very well tolerated — minimal side effects reported. It is a research chemical, not approved for human use.
Frequently Asked Questions
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Quick Reference
Research Use Only
This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.