What are the side effects of Mod GRF 1-29 & GHRP-2 Blend?

Side effects documented in research include: Moderate cortisol/prolactin elevation; Injection site reactions; Water retention. For educational reference only.

Peptide Blends

Mod GRF 1-29 & GHRP-2 Blend

A research blend pairing Mod GRF 1-29 with GHRP-2 for potent synergistic GH release. Functionally identical to CJC-1295 & GHRP-2 Blend but labeled under the Mod GRF 1-29 nomenclature.

C152H252N44O42S / C45H55N9O6Half-life: Mod GRF: ~30-60 min; GHRP-2: ~1 hour

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Compound Profile

Mod GRF 1-29 & GHRP-2 Blend

Key Data

FormulaC152H252N44O42S / C45H55N9O6

Half-lifeMod GRF: ~30-60 min; GHRP-2: ~1 hour

CategoryPeptide Blends

Research reference only

Research Focus

Same mechanism as CJC-1295 + GHRP-2

Strong GH pulse amplitude

Moderate cortisol/prolactin profile (better than GHRP-6)

Preclinical data

⚠ Research & Educational Use Only. Mod GRF 1-29 & GHRP-2 Blend is a research chemical documented here for scientific education. All information references peer-reviewed literature and preclinical/clinical study data. Not for human consumption. Not medical advice. Consult a licensed researcher or healthcare professional before any laboratory use.

Chemistry review: Ashish KumarWritten by the KnowYourPeptide Research TeamLast updated July 2026

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Key Takeaways

Same mechanism as CJC-1295 + GHRP-2
Strong GH pulse amplitude
Moderate cortisol/prolactin profile (better than GHRP-6)
Mod GRF 1-29 & GHRP-2 Blend is not FDA-approved for human use. It is a research chemical for scientific study only.

Research At a Glance

Same mechanism as CJC-1295 + GHRP-2
Strong GH pulse amplitude
Moderate cortisol/prolactin profile (better than GHRP-6)
Well-studied combination in research literature

Calculate Mod GRF 1-29 & GHRP-2 Blend dose

Who researches this:Researchers seeking maximum GH pulse amplitude with pulsatile kineticsThose comparing GHRP-2 vs ipamorelin as short-acting Mod GRF partner for GH outputPeople studying maximum GH secretagogue responses from pulsatile combinationsScientists investigating the endocrine profile (GH, cortisol, prolactin, IGF-1) of high-potency pulsatile GH protocols

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In Plain English

Simple summary

Mod GRF 1-29 + GHRP-2 is the maximum-potency pulsatile GH secretagogue combination -- short-acting GHRH with the strongest GH-releasing GHRP available. Each injection produces a large, sharp GH pulse that clears within 30 minutes. It's used in research protocols where maximum GH pulse amplitude with pulsatile kinetics is the design goal -- producing the strongest GH pulse per injection of any two-compound short-acting combination. The cortisol elevation from GHRP-2 accumulates with each dose as with all GHRP-2 protocols.

Same mechanism as CJC-1295 + GHRP-2
Strong GH pulse amplitude
Moderate cortisol/prolactin profile (better than GHRP-6)

The full scientific detail, mechanisms, citations, and dosing data, follows below.

What is Mod GRF 1-29 & GHRP-2 Blend?

Tap any underlined term for an instant definition.

The Mod GRF 1-29 & GHRP-2 Blend is functionally identical to the CJC-1295 (no DAC) & GHRP-2 blend, listed separately because researchers often use either "CJC-1295" or "Mod GRF 1-29" interchangeably to refer to the 4-substitution GHRH analogue without DAC modification.

What It Is

Mod GRF 1-29 = CJC-1295 without DAC: GHRH 1-29 with Ala2, Gln8 and two additional substitutions for DPP-IV resistance; half-life ~30-60 min
GHRP-2: potent GHS-R1a agonist; strong GH output with moderate cortisol/prolactin effects
Identical mechanism and expected outcomes to CJC-1295 (no DAC) + GHRP-2

Mechanism, Research Findings, and Dosing

Identical to CJC-1295 & GHRP-2 Blend
GH peaks 40-60 ng/mL in responsive subjects at standard doses
IGF-1 elevation 60-80% above baseline at 3 months
Cortisol: transient 20-25% elevation at peak concentration

Dosing From the Literature

Mod GRF 1-29 100-200 mcg + GHRP-2 100-200 mcg per injection
Twice daily on empty stomach

Storage and Handling

Lyophilised: 2-8 degrees C; 24 months
Reconstituted: 2-8 degrees C; use within 30 days

By the Numbers

Highest GH pulse per injection

Mod GRF + GHRP-2 produces the largest GH pulses of any two-compound short-acting combination

Cortisol elevation with each dose

GHRP-2's ACTH/cortisol co-stimulation occurs with every injection -- relevant for protocols involving multiple daily doses

30-minute clearance

Both compounds clear within 30 minutes -- produces complete pulse-then-return cycles suitable for physiology studies

Key Research Benefits

Documented effects observed in preclinical and clinical studies on Mod GRF 1-29 & GHRP-2 Blend. See all Peptide Blends peptides for comparison.

Same mechanism as CJC-1295 + GHRP-2

Strong GH pulse amplitude

Moderate cortisol/prolactin profile (better than GHRP-6)

Well-studied combination in research literature

Side Effects & Risks

Adverse effects reported in the research literature. All data sourced from preclinical and clinical study reports. View all peptides' side effects →

Dosing Data from the Literature

Doses referenced below are sourced from published preclinical and clinical studies. Use the peptide dose calculator to convert these values to injection volume.

Research Dosing Protocol

Mod GRF 1-29 100-200 mcg + GHRP-2 100-200 mcg per injection. Twice daily.

Enter your vial size and target dose to get the exact injection volume.

Administration in Research Settings

Standard reconstitution and administration methodology for laboratory research use.

Subcutaneous injection on empty stomach.

What the research doesn't show

GHRP-2's cortisol elevation is dose- and frequency-dependent. With 2-3 daily Mod GRF + GHRP-2 injections, cortisol is being repeatedly stimulated throughout the day. Whether this has meaningful HPA axis effects over weeks of use has not been rigorously studied. Researchers should factor the cortisol co-stimulation into protocol design when using GHRP-2-containing combinations.

Medical Expert Videos

Physicians, researchers, and pharmacologists explain Mod GRF 1-29 & GHRP-2 Blend, covering mechanisms of action, clinical context, and study findings.

YouTube, Mod GRF 1-29 & GHRP-2 Blend · doctors & researchersOpen in YouTube

Videos sourced from YouTube search. KnowYourPeptide does not endorse any individual creator. For research education only.

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The Bottom Line

Mod GRF 1-29 & GHRP-2 Blend has a growing body of preclinical evidence and a well-characterised safety profile in research settings. The most-studied application is: same mechanism as cjc-1295 + ghrp-2.

The most commonly reported side effect in research subjects is moderate cortisol/prolactin elevation. It is a research chemical, not approved for human use.

Research chemicalNot for human useEducational purposes only

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Explore Further

All Peptide Blends research peptides Full research peptide directory Mod GRF 1-29 & GHRP-2 Blend dose calculator Compare Mod GRF 1-29 & GHRP-2 Blend with other peptides Browse all research categories Full site index

Quick Reference

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How It Compares

Mod GRF + Ipamorelin gives pulsatile GH with lower amplitude but much cleaner endocrine selectivity. CJC-1295 + GHRP-2 gives the same cortisol-inclusive profile with sustained rather than pulsatile GH. For pure GH pulse magnitude research without caring about cortisol, Mod GRF + GHRP-2 is the short-acting benchmark.

Compare Mod GRF 1-29 & GHRP-2 Blend side-by-side

Research Use Only

This information is for educational research purposes only. This is not medical advice. Consult a qualified healthcare professional.