Cortagen

Cortagen is a synthetic tetrapeptide bioregulator belonging to the Khavinson peptide bioregulator series, specifically designed to support vascular endothelial and cardiovascular tissue function. Like Cardiogen (for cardiac muscle), Bronchogen (for lungs), and Chonluten (for bronchopulmonary tissue), Cortagen represents the vascular-targeted component of the Russian organ-specific bioregulator approach.

The vascular endothelium - the single-cell layer lining all blood vessels - is now understood to be a biologically active organ rather than simply a passive barrier. Endothelial cells regulate vasomotor tone through nitric oxide production, control coagulation, manage inflammatory cell trafficking, and maintain barrier function. Age-related endothelial dysfunction is an early step in cardiovascular disease progression, and restoring endothelial cell biology is a major therapeutic target.

Cortagen's development followed the same methodology as other Khavinson bioregulators: peptide sequences were isolated from vascular tissue and tested for tissue-specific gene regulatory effects. The hypothesis is that these short peptides can enter cells and interact with gene regulatory sequences, normalising patterns of protein synthesis in ageing or damaged vascular cells.

Russian clinical research has studied Cortagen in the context of cerebrovascular insufficiency, atherosclerosis, and post-stroke recovery. It is often used in combination with Cardiogen (cardiac tissue support) and Epitalon (neuroendocrine regulation) in comprehensive cardiovascular health bioregulator protocols.